Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation
John P. Clancy; Steven M. Rowe; Frank J. Accurso; Moira L. Aitken; Raouf Amin; Melissa A. Ashlock; Manfred Ballmann; Michael Boyle · 2011 · Thorax
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
BACKGROUND: VX-809, a cystic fibrosis transmembrane conductance regulator (CFTR) modulator, has been shown to increase the cell surface density of functional F508del-CFTR in vitro. METHODS: A randomised, double-blind, placebo-controlled…
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Metadata source: OpenAlex · DOI 10.1136/thoraxjnl-2011-200393