Rodent Models of Alzheimer’s Disease: Past Misconceptions and Future Prospects
Helen M Collins; Susan A. Greenfield · 2024 · International Journal of Molecular Sciences
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disease with no effective treatments, not least due to the lack of authentic animal models. Typically, rodent models recapitulate the effects but not causes of AD, such as cholinergic neuron loss: lesioning of cholinergic neurons mimics the cognitive decline reminiscent of AD but not its neuropathology. Alternative models rely on the overexpression of genes associated with familial AD, such as amyloid precursor protein, or have genetically amplified expression of mutant tau. Yet transgenic rodent models poorly replicate the neuropatho
Abstract by Helen M Collins; Susan A. Greenfield, International Journal of Molecular Sciences (2024) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/ijms25116222