Collagenase-mediated extracellular matrix targeting for enhanced drug penetration and therapeutic efficacy in nanoscale delivery systems for cancer therapy
Pengyu Gong; Fei Wang; Yixin Hua; Ying Jie; Jianxiang Chen; Yiting Qiao · 2025 · Journal of Nanobiotechnology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
The highly fibrotic extracellular matrix (ECM) constitutes a major barrier that restricts the penetration and delivery efficiency of anticancer drugs, particularly in fibrotic tumors such as pancreatic cancer, in which cancer-associated…
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Metadata source: OpenAlex · DOI 10.1186/s12951-025-03815-y