Z-scores outperform similar methods for analyzing CRISPR paralog synthetic lethality screens
Juihsuan Chou; Nazanin Esmaeili Anvar; Reem Elghaish; Junjie Chen; Traver Hart · 2025 · Genome Biology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Abstract Genetic screens offer a promising strategy for identifying tumor-specific therapeutic targets, but single-gene knockout screens often miss functionally redundant paralogs. Multiplex Cas9 and Cas12a CRISPR systems have been…
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Metadata source: Crossref · DOI 10.1186/s13059-025-03660-0