Orally active prostacyclin analogue beraprost sodium in patients with chronic kidney disease: a randomized, double-blind, placebo-controlled, phase II dose finding trial
Akio Kôyama; Toshiro Fujita; Fumitake Gejyo; Hideki Origasa; Masanao Isono; Hajimu Kurumatani; Kiyonobu Okada; Hiroyuki Kanoh · 2015 · BMC Nephrology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Evidence increasingly points to the importance of chronic hypoxia in the tubulointerstitium as a final common pathway to end-stage renal disease (ESRD). Beraprost sodium (BPS) is an orally active prostacyclin (PGI2) analogue demonstrating prevention of the progression of chronic kidney disease (CKD) in various animal models by maintaining renal blood flow and attenuating renal ischemic condition. METHODS: This multicenter, randomized, double-blind, placebo-controlled, phase II trial was designed to determine the recommended dose of the sustained-release form of BPS (TRK-100STP 120
Abstract by Akio Kôyama; Toshiro Fujita; Fumitake Gejyo; Hideki Origasa; Masanao Isono; Hajimu Kurumatani; Kiyonobu Okada; Hiroyuki Kanoh, BMC Nephrology (2015) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1186/s12882-015-0130-5