Alcohol use and cardiometabolic risk in the UK Biobank: A Mendelian randomization study
Joanna Lankester; Daniela Zanetti; Erik Ingelsson; Themistocles L. Assimes · 2021 · PLoS ONE
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Observational studies suggest alcohol use promotes the development of some adverse cardiometabolic traits but protects against others including outcomes related to coronary artery disease. We used Mendelian randomization (MR) to explore causal relationships between the degree of alcohol consumption and several cardiometabolic traits in the UK Biobank. Using the well-established ADH1B Arg47His variant (rs1229984) and up to 24 additional SNPs recently found to be associated with alcohol consumption in an independent dataset as instruments, we conducted two-stage least squares and inverse weighte
Abstract by Joanna Lankester; Daniela Zanetti; Erik Ingelsson; Themistocles L. Assimes, PLoS ONE (2021) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1371/journal.pone.0255801