Negative / Null Result ReportOpen accessMedicine

Functional MR Microimaging of Pancreatic β-Cell Activation

Barjor Gimi; Lara Leoni; Jose Oberholzer; Mark Braun; Jose Avila; Yong Wang; Tejal Desai; Louis H. Philipson · 2006 · Cell Transplantation

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

The increasing incidence of diabetes and the need to further understand its cellular basis has resulted in the development of new diagnostic and therapeutic techniques. Nonetheless, the quest to noninvasively ascertain β-cell mass and function has not been achieved. Manganese (Mn)-enhanced MRI is presented here as a tool to image β-cell functionality in cell culture and isolated islets. Similar to calcium, extracellular Mn was taken up by glucose-activated β-cells resulting in 200% increase in MRI contrast enhancement, versus nonactivated cells. Similarly, glucose-activated islets showed an in

Abstract by Barjor Gimi; Lara Leoni; Jose Oberholzer; Mark Braun; Jose Avila; Yong Wang; Tejal Desai; Louis H. Philipson, Cell Transplantation (2006) — licensed CC BY 4.0.

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