Population-scale sequencing resolves determinants of persistent EBV DNA
Sherry S. Y. Nyeo; Erin M. Cumming; Oliver S. Burren; Meghana S. Pagadala; Jacob C. Gutierrez; Thahmina A. Ali; Laura C. Kida; Yifan Chen · 2026 · Nature
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
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Abstract
Abstract Epstein–Barr virus (EBV) is an endemic herpesvirus implicated in autoimmunity, cancer and neurological disorders. Although primary infection is often subclinical, persistent EBV infection can drive immune dysregulation and long-term complications. Despite the ubiquity of infection, the determinants of EBV persistence following primary exposure remain poorly understood, although human genetic variation partially contributes to this phenotypic spectrum 1–3 . Here we demonstrate that existing whole genome sequencing (WGS) data of human populations can be used to quantify persistent EBV D
Abstract by Sherry S. Y. Nyeo; Erin M. Cumming; Oliver S. Burren; Meghana S. Pagadala; Jacob C. Gutierrez; Thahmina A. Ali; Laura C. Kida; Yifan Chen, Nature (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41586-025-10020-2