Novel variants in the PRDX6 Gene and the risk of Acute Lung Injury following major trauma
Localio A Russell; Bellamy Scarlett; Gallop Robert; Lanken Paul N; Feng Rui; Li Mingyao; Meyer Nuala; Aplenc Richard · 2011 · BMC Medical Genetics
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Background Peroxiredoxin 6 ( PRDX6 ) is involved in redox regulation of the cell and is thought to be protective against oxidant injury. Little is known about genetic variation within the PRDX6 gene and its association with acute lung injury (ALI). In this study we sequenced the PRDX6 gene to uncover common variants, and tested association with ALI following major trauma. Methods To examine the extent of variation in the PRDX6 gene, we performed direct sequencing of the 5' UTR, exons, introns and the 3' UTR in 25 African American cases and controls and 23 European American cases and c
Abstract by Localio A Russell; Bellamy Scarlett; Gallop Robert; Lanken Paul N; Feng Rui; Li Mingyao; Meyer Nuala; Aplenc Richard, BMC Medical Genetics (2011) — licensed CC BY 4.0.
About to run something similar?
Run an AI Precheck on your own design to catch failure modes like this one before you spend the time. Your first desk check is free.
Related failures
Association between triglycerides, known risk SNVs and conserved rare variation in SLC25A40 in a multi-ancestry cohort
Negative / Null Result ReportThe effect of FOXA2 rs1209523 on glucose-related phenotypes and risk of type 2 diabetes in Danish individuals
Negative / Null Result ReportHepatitis E virus infection results in acute graft failure after liver transplantation: a case report
Negative / Null Result ReportCurative effectiveness of high frequency ultrafiltration for renal edema with diuretic resistance
Negative / Null Result ReportAssociation analysis of a highly polymorphic CAG Repeat in the human potassium channel gene KCNN3 and migraine susceptibility
Negative / Null Result ReportInvestigation of LncRNAs expression in patients with hepatitis B virus
WASTE indexes this work — it does not host or republish it. Failure-type classification is automated and approximate.
Metadata source: DOAJ · DOI 10.1186/1471-2350-12-77