DWORF Gene Therapy Improves Cardiac Calcium Handling and Mitochondrial Function
Omar Brito‐Estrada; Yasuhide Kuwabara; Aaron M. Gibson; Keira R. Hassel; Michael L. Kamradt; Joseph P. Verry; N. Scott Blair; Michael J. Bround · 2025 · Circulation Research
WASTE classifies this as Replication Failure · AI classification, approximate
A previously reported effect did not replicate here — verify it holds before you build on it.
Abstract (excerpt)
BACKGROUND: Calcium (Ca 2+ ) dysregulation is a hallmark of heart failure, impairing excitation-contraction coupling and contributing to pathological remodeling. The sarco/endoplasmic reticulum Ca 2+ ATPase isoform 2a (SERCA2a) mediates Ca…
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WASTE indexes this work — it does not host or republish it. Failure-type classification is automated and approximate.
Metadata source: OpenAlex · DOI 10.1161/circresaha.125.326550