The efficacy of valproate in acute mania, bipolar depression and maintenance therapy for bipolar disorder: an overview of systematic reviews with meta-analyses
Flávio Kapczinski; Jair Mari; Luiz Henrique Junqueira Dieckmann; Daniel Prates-Baldez; Michel Haddad; Naielly Rodrigues da Silva · 2024 · BMJ Open
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Objective This study aims to conduct an overview on the comparative efficacy of valproate in acute mania, bipolar depression and maintenance treatment of bipolar disorder (BD).Method We performed an overview of systematic reviews with meta-analyses of randomised controlled trials (RCTs), registered in PROSPERO (CRD42024497749). We searched Medline and Cochrane Database of Systematic Reviews. Summary measures comparing valproate with placebo or other active drugs were described.Results We included 26 systematic reviews. For acute mania (31 RCTs, n=4376), valproate showed a significantly better
Abstract by Flávio Kapczinski; Jair Mari; Luiz Henrique Junqueira Dieckmann; Daniel Prates-Baldez; Michel Haddad; Naielly Rodrigues da Silva, BMJ Open (2024) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1136/bmjopen-2024-087999