Biologics for bone regeneration: advances in cell, protein, gene, and mRNA therapies
Claudia Del Toro Runzer; Elizabeth R. Balmayor; Martijn van Griensven · 2026 · Bone Research
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Bone fractures represent a significant global healthcare burden. Although fractures typically heal on their own, some fail to regenerate properly, leading to nonunion, a condition that causes prolonged disability, morbidity, and mortality. The challenge of treating nonunion fractures is further complicated in patients with underlying bone disorders where systemic and local factors impair bone healing. Traditional treatment approaches, including autografts, allografts, xenografts, and synthetic biomaterials, face limitations such as donor site pain, immune rejection, and insufficient mechanical
Abstract by Claudia Del Toro Runzer; Elizabeth R. Balmayor; Martijn van Griensven, Bone Research (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41413-025-00487-0