Investigating the Effect of a Topical Ointment Prepared from the Ferfion Plant (Euphorbia macroclada Boiss.) on Clinical Symptoms in Patients with Primary Knee Osteoarthritis: A Double-Blind Randomized Clinical Trial
Amirsaeed Hosseini; Mohammad Yousofpour; Faranak Zaker; Hossein Azadeh; Ali Bijani; Maryam Khoshnazar; Maedeh Bagheri; Moloud Fakhri · 2026 · Journal of Mazandaran University of Medical Sciences
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Background and purpose: Osteoarthritis is the most common cause of knee pain and has various treatment modalities. The Ferfion plant is a significant medicinal plant in traditional medicine used worldwide. This study aimed to investigate the effect of Ferfion herbal ointment on the clinical symptoms of patients with primary knee osteoarthritis. Materials and methods: This double-blind, randomized clinical trial was conducted on 50 patients with primary knee osteoarthritis at Baghban Clinic. Patients were divided into two groups of 25, receiving either Ferfion ointment or a placebo. The first g
Abstract by Amirsaeed Hosseini; Mohammad Yousofpour; Faranak Zaker; Hossein Azadeh; Ali Bijani; Maryam Khoshnazar; Maedeh Bagheri; Moloud Fakhri, Journal of Mazandaran University of Medical Sciences (2026) — licensed CC BY 4.0.
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