Sex-biased computations underlying differential set shift performance in mice
Nic Glewwe; Evan M. Dastin-van Rijn; Cathy S. Chen; Erin Giglio; Evan Knep; R. Becket Ebitz; Alik S. Widge; Nicola M. Grissom · 2026 · Neuropsychopharmacology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Cognitive flexibility can be defined as the ability to adaptively shift between choices or strategies based on environmental feedback. Flexibility is disrupted in numerous neuropsychiatric conditions. Individual differences in the computations supporting cognitive flexibility may reveal mechanisms of neuropsychiatric risk and resilience. One critical variable well known to influence individual differences in neuropsychiatric risk is sex. While previous research has identified sex differences in value based decision making in mice, whether sex reflects a major source of variation in cognitive f
Abstract by Nic Glewwe; Evan M. Dastin-van Rijn; Cathy S. Chen; Erin Giglio; Evan Knep; R. Becket Ebitz; Alik S. Widge; Nicola M. Grissom, Neuropsychopharmacology (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41386-026-02397-z