Efficacy of Sym004 in Patients With Metastatic Colorectal Cancer With Acquired Resistance to Anti-EGFR Therapy and Molecularly Selected by Circulating Tumor DNA Analyses
Clara Montagut; Guillem Argilés; Fortunato Ciardiello; Thomas T. Poulsen; Rodrigo Dienstmann; Michael Kragh; Scott Kopetz; Trine Lindsted · 2018 · JAMA Oncology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
IMPORTANCE: Acquired resistance to anti-EGFR therapy (epidermal growth factor receptor) is frequently due to RAS and EGFR extracellular domain (ECD) mutations in metastatic colorectal cancer (mCRC). Some anti-EGFR-refractory patients…
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Metadata source: OpenAlex · DOI 10.1001/jamaoncol.2017.5245