Ziltivekimab in heart failure with preserved and mildly reduced ejection fraction: rationale and design of the ATHENA and HERMES trials
Guiomar Mendieta; Paul M. Ridker; Barry A. Borlaug; Anique Ducharme; Carolyn S.P. Lam; Adriaan A. Voors; Pernille Auerbach; Maja Čikeš · 2026 · European Journal of Heart Failure
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
AIMS: We hypothesized that targeting interleukin-6-a cytokine central to NOD-like receptor protein 3 (NLRP3) inflammasome activation that is associated with both the onset and progression of heart failure (HF)-may be beneficial in patients with HF and circulating evidence of cardiovascular inflammation but without overtly reduced ejection fraction (EF). We describe the rationale and design of two clinical trials (ATHENA and HERMES) investigating ziltivekimab, a human monoclonal antibody directed against the interleukin-6 ligand, in patients with HF and mildly reduced or preserved EF (HFmrEF/HF
Abstract by Guiomar Mendieta; Paul M. Ridker; Barry A. Borlaug; Anique Ducharme; Carolyn S.P. Lam; Adriaan A. Voors; Pernille Auerbach; Maja Čikeš, European Journal of Heart Failure (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1093/ejhf/xuag153