Formulation approaches for colon-specific drug delivery: conventional to nanocarrier systems
Ashish Sriram Mishra; Bhavna Ghosh; Sivakumar Ponnurengam Malliappan; Gouranga Dutta; M. Vasanthan M. Vasanthan · 2026 · RSC Advances
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
The development of colon-targeted drug delivery systems (CDDS) has gained increasing attention due to their potential to improve therapeutic outcomes for diseases such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), colorectal cancer, and other colonic disorders. Targeted delivery to the colon offers the advantages of site-specific action, reduced systemic side effects, and improved patient compliance. However, several physiological barriers, such as variable pH, microbial metabolism, enzymatic degradation, and transit time, pose significant formulation challenges. This re
Abstract by Ashish Sriram Mishra; Bhavna Ghosh; Sivakumar Ponnurengam Malliappan; Gouranga Dutta; M. Vasanthan M. Vasanthan, RSC Advances (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1039/d5ra05194k