A Comparative Analysis of Grip Strength Evaluation Methods in a Large Cohort of Aged Mice
Giorgia Bigossi; Serena Marcozzi; Maria Elisa Giuliani; Giovanni Lai; Beatrice Bartozzi; Fiorenza Orlando; Laura Gerosa; Amir Mohammad Malvandi · 2025 · Journal of Cachexia Sarcopenia and Muscle
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Grip strength is a key functional marker of musculoskeletal aging, widely used to assess sarcopenia. In preclinical research, multiple measurement methods are often combined to enhance reliability, but standardization remains challenging. To improve measurement robustness, we previously developed a composite strength score (SS5) that integrates five different grip strength tests into a single variable. While SS5 provides a comprehensive evaluation, its implementation is time-consuming, limiting feasibility in large-scale studies. In this study, we also examine two simplified compos
Abstract by Giorgia Bigossi; Serena Marcozzi; Maria Elisa Giuliani; Giovanni Lai; Beatrice Bartozzi; Fiorenza Orlando; Laura Gerosa; Amir Mohammad Malvandi, Journal of Cachexia Sarcopenia and Muscle (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1002/jcsm.70050