Pulsatile sequential drug release system for cascade tumor deep penetration and differentiation therapy to enhance chemoimmunotherapy
Fengxiang Liu; Shipeng Ning; Xia Wang; Xiaoyuan Fan; Bin Wan; Fei Sun; Lili Du; Ke Shi · 2025 · Science Advances
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Cancer stem cells (CSCs) and myeloid-derived suppressor cells (MDSCs) contribute to chemoresistance and immunosuppression, constraining chemoimmunotherapy outcomes. Differentiation therapy, aiming to mature CSCs and MDSCs, shows great promise. However, its efficacy is hindered by limited accessibility in hypoxic deep tumor regions. Inspired by the apoptotic body (ApoBD)-mediated deep tumor penetration, we design a pulsatile sequential drug release system with a core-shell structure. The reversible acid-responsive shell protonates and swells in lysosomes to release doxorubicin, inducing lysosom
Abstract by Fengxiang Liu; Shipeng Ning; Xia Wang; Xiaoyuan Fan; Bin Wan; Fei Sun; Lili Du; Ke Shi, Science Advances (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1126/sciadv.adr8001