Non-invasive temporal interference stimulation of the hippocampus suppresses epileptic biomarkers in patients with Epilepsy: biophysical differences between kilohertz and amplitude modulated stimulation
Florian Missey; Emma Acerbo; Adam S. Dickey; Jan Trajlínek; Ondřej Studnička; Claudia Lubrano; Mariane de Araújo e Silva; Evan Brady · 2025 · Brain stimulation
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
INTRODUCTION: Medication-refractory focal epilepsy creates a significant clinical challenge, with approximately 30 % of patients deemed ineligible for surgery due to involvement of eloquent cortical regions within the epileptogenic network. For these patients, electrical neuromodulation represents a promising alternative therapy. We investigated the potential of non-invasive temporal interference (TI) electrical stimulation in reducing epileptic biomarkers in patients with mesiotemporal epilepsy (MTLE) MATERIAL AND METHOD: Thirteen patients implanted with stereoelectroencephalography (sEEG) de
Abstract by Florian Missey; Emma Acerbo; Adam S. Dickey; Jan Trajlínek; Ondřej Studnička; Claudia Lubrano; Mariane de Araújo e Silva; Evan Brady, Brain stimulation (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1016/j.brs.2025.11.008