Replication FailureOpen accessMedicine· cited by 10

Randomized trial investigating the utility of a liver tissue transcriptional biomarker in identifying adult liver transplant recipients not requiring maintenance immunosuppression

Julien Vionnet; Jorge P. Torres-Yaguana; Rosa Miquel; Juan G. Abraldeṣ; Jurate Wall; Elisavet Kodela; Juan José Lozano; Pablo Ruíz · 2024 · American Journal of Transplantation

WASTE classifies this as Replication Failure · AI classification, approximate

A previously reported effect did not replicate here — verify it holds before you build on it.

Abstract

The maintenance of stable allograft status in the absence of immunosuppression (IS), known as operational tolerance, can be achieved in a small proportion of liver transplant recipients, but we lack reliable tools to predict its spontaneous development. We conducted a prospective, multicenter, biomarker-strategy design, IS withdrawal clinical trial to determine the utility of a predictive biomarker of operational tolerance. The biomarker test, originally identified in a patient cohort with high operational tolerance prevalence, consisted of a 5-gene transcriptional signature measured in liver

Abstract by Julien Vionnet; Jorge P. Torres-Yaguana; Rosa Miquel; Juan G. Abraldeṣ; Jurate Wall; Elisavet Kodela; Juan José Lozano; Pablo Ruíz, American Journal of Transplantation (2024) — licensed CC BY 4.0.

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