Toxicity of Parasporin-4 and Health Effects of Pro-parasporin-4 Diet in Mice
Shiro Okumura; Hironori Koga; Kuniyo Inouye; Eiichi Mizuki · 2014 · Toxins
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Parasporin-4 (PS4) is an aerolysin-type β-pore-forming toxin produced by Bacillus thuringiensis strain A1470. It exhibits specific cytotoxicity against human cancer cell lines; therefore, it is expected to be useful for the diagnosis and treatment of particular types of cancer cells. We examined the acute toxicity of PS4 on ICR mice. The LD50 value was 160 μg/kg by a subcutaneous route. Potassium, ammonium, magnesium ion, creatinine, and urea nitrogen decreased in urine by the injection of PS4. Simultaneously, creatinine and urea nitrogen in mice serum increased. These results imply that PS4 i
Abstract by Shiro Okumura; Hironori Koga; Kuniyo Inouye; Eiichi Mizuki, Toxins (2014) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3390/toxins6072115