Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial
Philippe Bégin; Jeannie Callum; Erin Jamula; Richard J. Cook; Nancy M. Heddle; Alan Tinmouth; Michelle P. Zeller; Guillaume Beaudoin-Bussières · 2021 · Nature Medicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
The efficacy of convalescent plasma for coronavirus disease 2019 (COVID-19) is unclear. Although most randomized controlled trials have shown negative results, uncontrolled studies have suggested that the antibody content could influence patient outcomes. We conducted an open-label, randomized controlled trial of convalescent plasma for adults with COVID-19 receiving oxygen within 12 d of respiratory symptom onset ( NCT04348656 ). Patients were allocated 2:1 to 500 ml of convalescent plasma or standard of care. The composite primary outcome was intubation or death by 30 d. Exploratory analyses
Abstract by Philippe Bégin; Jeannie Callum; Erin Jamula; Richard J. Cook; Nancy M. Heddle; Alan Tinmouth; Michelle P. Zeller; Guillaume Beaudoin-Bussières, Nature Medicine (2021) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41591-021-01488-2