Effects of Mu-Opiate Receptor Gene Polymorphism rs1799971 (A118G) on the Antidepressant and Dissociation Responses in Esketamine Nasal Spray Clinical Trials
Ziad S. Saad; Derrek P. Hibar; Maggie Fedgchin; Vanina Popova; Maura L. Furey; Jaskaran Singh; Hartmuth C. Kolb; Wayne C. Drevets · 2020 · The International Journal of Neuropsychopharmacology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
BACKGROUND: At ketamine and esketamine doses at which antidepressant doses are achieved, these agents are relatively selective, noncompetitive, N-methyl-D-aspartate receptor antagonists. However, at substantially higher doses, ketamine has…
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Metadata source: OpenAlex · DOI 10.1093/ijnp/pyaa030