From bench to bedside: translating mesenchymal stem cell therapies through preclinical and clinical evidence
Jai Chand Patel; Meenakshi Shukla; Manish Shukla; Manish Shukla; Manish Shukla · 2025 · Frontiers in Bioengineering and Biotechnology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Mesenchymal stem cells (MSCs) are emerging as a powerful tool in regenerative medicine due to their ability to differentiate into mesenchymal lineages, such as bone, cartilage, and fat, along with their low immunogenicity and strong immunomodulatory properties. Unlike traditional cell therapies that rely on engraftment, MSCs primarily function through paracrine signaling-secreting bioactive molecules like vascular endothelial growth factor (VEGF), transforming growth factor-beta (TGF-β), and exosomes. These factors contribute to tissue repair, promote angiogenesis, and modulate immune response
Abstract by Jai Chand Patel; Meenakshi Shukla; Manish Shukla; Manish Shukla; Manish Shukla, Frontiers in Bioengineering and Biotechnology (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fbioe.2025.1639439