Suzetrigine (VX-548) exhibits activity-dependent effects on human dorsal root ganglion neurons with differential pain etiology
Megan L. Uhelski; Mandee K. Schaub; Felipe Espinosa; Mario Heles; Nicolas Cortes; Yan Li; Claudio Esteves Tatsui; Lawrence D. Rhines · 2026 · Pain
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
ABSTRACT: Nonselective antagonists of voltage-gated sodium channels (VGSCs) provide effective local analgesia, but systemic administration is fraught with unwanted cardiovascular and central nervous system toxicity. The development of…
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Metadata source: OpenAlex · DOI 10.1097/j.pain.0000000000003931