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Abandoned HypothesisMedicine

Is active surveillance of CIN2 always appropriate? Clinical outcomes and factors associated with progression and regression over 48 months in an HPV-positive cohort.

Bruno MT; Pagana A; Aiello T; Pivetti E; Cavallaro AG; Tarascio M; Panella MM; Valenti G · 2026 · BMC cancer

WASTE classifies this as Abandoned Hypothesis · AI classification, approximate

A hypothesis was tested and not supported — a dead end worth knowing about before you pursue it.

Abstract (excerpt)

Background Active surveillance of cervical intraepithelial neoplasia grade 2 (CIN2) is increasingly adopted to reduce the risk of overtreatment, particularly in young women. However, the appropriateness of this approach remains debated,…

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Metadata source: Europe PMC · DOI 10.1186/s12885-026-16398-0