Melatonin Prevents Thymic Atrophy but Does Not Protect Against Disruption of T Cell Maturation Related to Cyclophosphamide Exposure.
Pimenta GF; Dourado TMH; de Souza KDB; Elias-Oliveira J; Rodrigues VF; Carlos D; Tirapelli CR · 2025 · Cell biochemistry and function
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Increased oxidative stress and apoptosis are key mechanisms of thymic atrophy induced by cyclophosphamide (CYP). Atrophy leads to changes in the thymic microenvironment and disrupts T cell maturation. The hormone melatonin displays…
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Metadata source: Europe PMC · DOI 10.1002/cbf.70052