A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies
Steffen Boettcher; Peter G. Miller; Rohan Sharma; Marie McConkey; Matthew Leventhal; Andrei V. Krivtsov; Andrew O. Giacomelli; Waihay J. Wong · 2019 · Science
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
p53—still hazy after all these years? The gene encoding the p53 tumor suppressor protein is the most frequently mutated gene in human cancer. Yet decades after the gene's discovery, the biology of cancer-associated missense mutations in…
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Metadata source: OpenAlex · DOI 10.1126/science.aax3649