Characterisation of age and polarity at onset in bipolar disorder
János Kálmán; Loes M. Olde Loohuis; Annabel Vreeker; Andrew McQuillin; Eli A. Stahl; Douglas M. Ruderfer; Maria Grigoroiu‐Serbânescu; Georgia Panagiotaropoulou · 2021 · The British Journal of Psychiatry
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The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
BACKGROUND: Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools. AIMS: To examine the genetic architecture of AAO and PAO and their association with bipolar disorder disease characteristics. METHOD: Genome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (n = 12 977) and PAO (n = 6773) were conducted in patients with bipolar disorder from 34 cohorts and a replication sample (n = 2237). The association of on
Abstract by János Kálmán; Loes M. Olde Loohuis; Annabel Vreeker; Andrew McQuillin; Eli A. Stahl; Douglas M. Ruderfer; Maria Grigoroiu‐Serbânescu; Georgia Panagiotaropoulou, The British Journal of Psychiatry (2021) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1192/bjp.2021.102