Harnessing Hybrid Niosomes for Improved Oral Bioavailability of an Anticoagulant: Design, Optimization and In-Vivo Pharmacokinetics and Pharmacodynamics Evaluations
Remonda Raafat Ragheb; Rodayana Atef; Kareem Abdou; Sadek Ahmed; Ahmed M. Fatouh · 2026 · AAPS PharmSciTech
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Venous thromboembolism (VTE) and pulmonary embolism (PE), remains a major global health burden, necessitating prolonged and reliable anticoagulant therapy. Although Apixaban (APX) is a cornerstone oral anticoagulant for VTE management, its therapeutic performance is limited by poor aqueous solubility and low oral bioavailability. To overcome these challenges, this study introduces a hybrid niosomal delivery system designed to enhance the absorption and systemic persistence of APX. The system was engineered by integrating hybrid of surfactants together with cholesterol to form a stable
Abstract by Remonda Raafat Ragheb; Rodayana Atef; Kareem Abdou; Sadek Ahmed; Ahmed M. Fatouh, AAPS PharmSciTech (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1208/s12249-026-03374-x