Type 2 Diabetes and the Multifaceted Gut-X Axes
Hezixian Guo; L.-T. Pan; Qiuyi Wu; Linhao Wang; Zongjian Huang; Jie Wang; Li Wang; Xiang Fang · 2025 · Nutrients
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Type 2 diabetes (T2D) is a complex metabolic disease characterized by chronic hyperglycemia due to insulin resistance and inadequate insulin secretion. Beyond the classically implicated organs, emerging evidence highlights the gut as a central player in T2D pathophysiology through its interactions with metabolic organs. The gut hosts trillions of microbes and enteroendocrine cells that influence inflammation, energy homeostasis, and hormone regulation. Disruptions in gut homeostasis (dysbiosis and increased permeability) have been linked to obesity, insulin resistance, and β-cell dysfunction,
Abstract by Hezixian Guo; L.-T. Pan; Qiuyi Wu; Linhao Wang; Zongjian Huang; Jie Wang; Li Wang; Xiang Fang, Nutrients (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/nu17162708