Multiple system atrophy: an update and emerging directions of biomarkers and clinical trials
Min Liu; Zhiyao Wang; Huifang Shang · 2024 · Journal of Neurology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Multiple system atrophy is a rare, debilitating, adult-onset neurodegenerative disorder that manifests clinically as a diverse combination of parkinsonism, cerebellar ataxia, and autonomic dysfunction. It is pathologically characterized by oligodendroglial cytoplasmic inclusions containing abnormally aggregated α-synuclein. According to the updated Movement Disorder Society diagnostic criteria for multiple system atrophy, the diagnosis of clinically established multiple system atrophy requires the manifestation of autonomic dysfunction in combination with poorly levo-dopa responsive parkinsoni
Abstract by Min Liu; Zhiyao Wang; Huifang Shang, Journal of Neurology (2024) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1007/s00415-024-12269-5