The Influence of TDP1 Inhibitor Usnic Acid Derivative OL9-116 on the Effects of Topotecan in Human Cells.
Kornienko TE; Chepanova AA; Kolobenko MV; Chernyshova IA; Zakharenko AL; Venzel AS; Dyrkheeva NS; Markov AV · 2026 · Current issues in molecular biology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a key enzyme for the repair of stalled topoi-somerase 1 (TOP1)-DNA complexes. We have previously developed a TDP1 inhibitor, compound OL9-116, which is capable of enhancing the action of the…
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Metadata source: Europe PMC · DOI 10.3390/cimb48040428