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Negative / Null Result ReportOpen accessMedicine

Efficacy and safety of azvudine versus nirmatrelvir/ritonavir in cancer patients with COVID-19

Bohan Jia; Junyi Sun; Di Zhu; Ling Wang; Xiaobo Hu; Haiyu Wang; Guowu Qian; Donghua Zhang · 2025 · Scientific Reports

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

Abstract Cancer significantly contributes to the unfavorable prognosis of coronavirus disease 2019 (COVID-19) patients. The efficacy and safety of azvudine and nirmatrelvir/ritonavir (Paxlovid) in cancer patients with COVID-19 remain uncertain. Therefore, we designed a comprehensive retrospective study encompassing clinical data of 32,864 hospitalized COVID-19 patients, 691 of whom were cancer patients treated with azvudine and 200 were cancer patients treated with Paxlovid. After 2:1 propensity score matching, 397 patients in the azvudine group and 199 patients in the Paxlovid group were enro

Abstract by Bohan Jia; Junyi Sun; Di Zhu; Ling Wang; Xiaobo Hu; Haiyu Wang; Guowu Qian; Donghua Zhang, Scientific Reports (2025) — licensed CC BY 4.0.

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Metadata source: DOAJ · DOI 10.1038/s41598-025-85677-w