Phase 2 Futility Trials in Alzheimer Disease and Mild Cognitive Impairment: A Cohort Analysis of the ADNI Data Set.
Ganesh A; Smith EE; Mostert J; Strijbis EM; Schoonheim MM; Xia C; Nadeau Y; Leavitt VM · 2026 · Neurology
WASTE classifies this as Failed Experiment Report · AI classification, approximate
An experimental approach did not work as intended — learn what to avoid before investing the same effort.
Abstract (excerpt)
Background and objectives The cost and complexity of phase 2 randomized-controlled trials (RCTs) hinder further development of promising treatment candidates for Alzheimer disease (AD). The Simon Two-Stage futility trial design, originally…
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Metadata source: Europe PMC · DOI 10.1212/wnl.0000000000218227