Replication FailureOpen accessMedicine· cited by 9

Long-term outcomes of genicular artery embolization for knee osteoarthritis: 12-month efficacy and secondary outcomes from a randomized sham-controlled clinical trial

Tijmen A. van Zadelhoff; Rianne A. van der Heijden; Sita M. A. Bierma-Zeinstra; Pieter Koen Bos; Edwin H. G. Oei · 2026 · European Radiology

WASTE classifies this as Replication Failure · AI classification, approximate

A previously reported effect did not replicate here — verify it holds before you build on it.

Abstract

OBJECTIVES: To determine if genicular artery embolization (GAE) is more effective in relieving pain symptoms after 12 months compared to a sham procedure in patients with mild to moderate knee osteoarthritis. A secondary aim was to investigate changes in synovitis observed at 4 months and the correlation with other clinical outcomes. MATERIALS AND METHODS: A randomized controlled trial included patients with mild to moderate knee osteoarthritis unresponsive to conservative treatment, who were randomly assigned to receive either GAE or sham treatment. Follow-up was at 1, 4, 8, and 12 months. Pa

Abstract by Tijmen A. van Zadelhoff; Rianne A. van der Heijden; Sita M. A. Bierma-Zeinstra; Pieter Koen Bos; Edwin H. G. Oei, European Radiology (2026) — licensed CC BY 4.0.

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