CDK2 inhibitor BLU-222 synergizes with CDK4/6 inhibitors in drug resistant breast cancers through p21/p27 induction
Linjie Luo; Yan Wang; Tuyen Bui; Xiaoting Jiang; Mei-Kuang Chen; Xiayu Rao; Sepideh Mohammadhosseinpour; Mi Li · 2026 · Nature Communications
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy are the standard first-line treatment for hormone receptor-positive, HER2−negative (HR+/HER2−) metastatic breast cancer, but resistance inevitably develops.…
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Metadata source: OpenAlex · DOI 10.1038/s41467-025-67865-4