A 3D spheroid model for assessing nanocarrier-based drug delivery to solid tumors
Chitra Yadav; Alexander S. Evtushenko; Andrea Bistrović; Beatriz Lozano Torres; Ishtiaq Ahmed; Liuba Dvinskikh; Clemens F. Kaminski; Ljiljana Fruk · 2025 · npj Biomedical Innovations.
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
3D spheroid culture has emerged as a valuable tool for studying complex intratumoral processes and screening novel therapeutics in vitro. However, spheroids face reproducibility and data interpretation issues, which limit their utility. This work describes a simple and reproducible co-culture spheroid model compatible with high-throughput screening designed to study pancreatic ductal adenocarcinoma (PDAC), a highly therapy-resistant cancer. These spheroids, composed of both cancer and stromal cells, recapitulate key features of PDAC which are difficult to study in traditional 2D cell culture,
Abstract by Chitra Yadav; Alexander S. Evtushenko; Andrea Bistrović; Beatriz Lozano Torres; Ishtiaq Ahmed; Liuba Dvinskikh; Clemens F. Kaminski; Ljiljana Fruk, npj Biomedical Innovations. (2025) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s44385-025-00041-x