Report: The effects of topical pleurotus tuberregium (PT) aqueous extract on intraocular pressure in monkeys.
Ghalib A Akinlabi; Paul L Kaufman; Julie A Kiland · 2021 · PLoS ONE
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Purpose In earlier experiments in Nigeria, aqueous extract of Pleurotus tuber-regium (PT) had been shown to lower intra ocular pressure (IOP) in a feline model. The aim of the current study was to determine whether PT had the same or a similar IOP-lowering effect in ocularly normal non-human primates. Methods Four monkeys were treated twice daily for 4 days with 2 x 20 μl drops of 50 mg/ml PT (pH = 4.3). The monkeys were sedated with 5-10 mg/kg ketamine HCl IM. PT was administered to the right eye and BSS to the left eye. Baseline IOP was measured just prior to beginning treatment, and on day
Abstract by Ghalib A Akinlabi; Paul L Kaufman; Julie A Kiland, PLoS ONE (2021) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1371/journal.pone.0256422