Immunization with a Trypanosoma cruzi cyclophilin-19 deletion mutant protects against acute Chagas disease in mice
Bijay Kumar Jha; Sanjay Varikuti; Chaitenya Verma; Rahul Shivahare; Nicholas Bishop; Gregory Pedroso dos Santos; Jacquelyn McDonald; Aakash Sur · 2023 · npj Vaccines
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Human infection with the protozoan parasite Trypanosoma cruzi causes Chagas disease for which there are no prophylactic vaccines. Cyclophilin 19 is a secreted cis-trans peptidyl isomerase expressed in all life stages of Trypanosoma cruzi. This protein in the insect stage leads to the inactivation of insect anti-parasitic peptides and parasite transformation whereas in the intracellular amastigotes it participates in generating ROS promoting the growth of parasites. We have generated a parasite mutant with depleted expression of Cyp19 by removal of 2 of 3 genes encoding this protein using doubl
Abstract by Bijay Kumar Jha; Sanjay Varikuti; Chaitenya Verma; Rahul Shivahare; Nicholas Bishop; Gregory Pedroso dos Santos; Jacquelyn McDonald; Aakash Sur, npj Vaccines (2023) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1038/s41541-023-00647-5