Negative / Null Result ReportOpen accessMedicine· cited by 18

Identification, Molecular Cloning, and Analysis of Full-Length Hepatitis C Virus Transmitted/Founder Genotypes 1, 3, and 4

Mark B. Stoddard; Hui Li; Shuyi Wang; Mohsan Saeed; Linda Andrus; Wenge Ding; Xinpei Jiang; Gerald H. Learn · 2015 · mBio

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

UNLABELLED: Hepatitis C virus (HCV) infection is characterized by persistent replication of a complex mixture of viruses termed a "quasispecies." Transmission is generally associated with a stringent population bottleneck characterized by infection by limited numbers of "transmitted/founder" (T/F) viruses. Characterization of T/F genomes of human immunodeficiency virus type 1 (HIV-1) has been integral to studies of transmission, immunopathogenesis, and vaccine development. Here, we describe the identification of complete T/F genomes of HCV by single-genome sequencing of plasma viral RNA from a

Abstract by Mark B. Stoddard; Hui Li; Shuyi Wang; Mohsan Saeed; Linda Andrus; Wenge Ding; Xinpei Jiang; Gerald H. Learn, mBio (2015) — licensed CC BY 4.0.

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