Immunogenicity of HIV-1 Vaccines Expressing Chimeric Envelope Glycoproteins on the Surface of Pr55 Gag Virus-Like Particles
Rosamund Chapman; Michiel van Diepen; Shireen Galant; Elizabeth Kruse; Emmanuel Margolin; Phindile Ximba; Tandile Hermanus; Penny Moore · 2020 · Vaccines
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
The HIV-1 envelope glycoprotein (Env) is present on the surface of the virion at a very low density compared to most other enveloped viruses. Substitution of various parts of the stalk domain of Env (gp41) with the corresponding elements from other viral glycoproteins has been shown to increase Env spike density on the cell membrane and surface of virus-like particles (VLPs). In this study, chimeric Env antigens were generated by replacing the transmembrane and cytoplasmic domains of HIV-1 Env with the corresponding regions from the influenza H5 hemagglutinin (HA) (gp140HA 2 tr) and by replaci
Abstract by Rosamund Chapman; Michiel van Diepen; Shireen Galant; Elizabeth Kruse; Emmanuel Margolin; Phindile Ximba; Tandile Hermanus; Penny Moore, Vaccines (2020) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3390/vaccines8010054