Functional co-activation of the default mode network in APOE ε4-carriers: A replication study
Lara J. Mentink; Joao Guimaraes; Myrthe Faber; Emma Sprooten; Marcel G. M. Olde Rikkert; Koen V. Haak; Christian F. Beckmann · 2021 · NeuroImage
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Structural and functional alterations of the brain in persons genetically at-risk for Alzheimer's disease (AD) are crucial in unravelling AD development. Filippini et al. found that the default mode network (DMN) is already affected in young APOE ε4-carriers, with increased co-activation of the DMN during rest and increased hippocampal task activation. We aimed to replicate the early findings of Filippini et al, using the APOE gene, still the principal AD risk gene, and extended this with a polygenic risk score (PRS) analysis for AD, using the Human Connectome Project dataset (HCP). We include
Abstract by Lara J. Mentink; Joao Guimaraes; Myrthe Faber; Emma Sprooten; Marcel G. M. Olde Rikkert; Koen V. Haak; Christian F. Beckmann, NeuroImage (2021) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1016/j.neuroimage.2021.118304