Improvement of cardiac function by Ivabradine in a doxorubicin-induced cardiomyopathy murine model is associated with a normal renal angiotensin II type I receptor expression but not with a reduction in fibrosis.
Drumeva GO; Plane AF; Petrenyov DR; Ribeiro PAB; Chen C; DaSilva JN; Tournoux FB · 2026 · Cardio-oncology (London, England)
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
BACKGROUND: Ivabradine (IVAB) is an effective drug in patients with heart failure (HF). However, data in the context of chemotherapy-induced cardiomyopathy are limited. This study investigated the cardioprotective potential of IVAB in a…
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Metadata source: Europe PMC · DOI 10.1186/s40959-026-00469-z