Treatment of indolent systemic mastocytosis with sarilumab is not supported in a randomized trial.
Komarow HD; Wang J; Eisch R; Scott L; Brittain EH; Metcalfe DD · 2025 · The journal of allergy and clinical immunology. Global
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Background Indolent systemic mastocytosis is a clonal mast cell disease that results in an increase in mast cells in the skin, bone marrow, and other organ systems. IL-6 has been shown to promote mast cell maturation, proliferation, and…
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Metadata source: Europe PMC · DOI 10.1016/j.jacig.2025.100498