Oxygen level alters energy metabolism in bovine preimplantation embryos
Nina Boskovic; Marilin Ivask; Gamze Yazgeldi Gunaydin; Barış Yaşar; Shintaro Katayama; Andres Salumets; Tõnis Org; Ants Kurg · 2025 · Scientific Reports
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Mammalian preimplantation embryo development is a complex sequence of events. This period of development is sensitive to oxygen (O 2 ) levels that can affect various cellular processes. We compared the influence of O 2 tension by culturing embryos either in normoxic (20% O 2 ) or physiological hypoxic (6% O 2 ) conditions, or sequential low O 2 concentration starting with 6% O 2 until 16-cell stage and then switching to ultrahypoxic conditions (2% O 2 ). Due to ethical concerns, we used bovine as an animal model with a good similarity of embryogenesis to human. We found that the cleav
Abstract by Nina Boskovic; Marilin Ivask; Gamze Yazgeldi Gunaydin; Barış Yaşar; Shintaro Katayama; Andres Salumets; Tõnis Org; Ants Kurg, Scientific Reports (2025) — licensed CC BY 4.0.
About to run something similar?
Run an AI Precheck on your own design to catch failure modes like this one before you spend the time. Your first desk check is free.
Related failures
A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke
Negative / Null Result ReportDuodenal Infusion of Donor Feces for Recurrent Clostridium difficile
Negative / Null Result ReportStenting versus Endarterectomy for Treatment of Carotid-Artery Stenosis
Negative / Null Result ReportEffects of Combination Lipid Therapy in Type 2 Diabetes Mellitus
Replication FailureA Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma
Negative / Null Result ReportSpironolactone for Heart Failure with Preserved Ejection Fraction
WASTE indexes this work — it does not host or republish it. Failure-type classification is automated and approximate.
Metadata source: OpenAlex · DOI 10.1038/s41598-025-95990-z