A phase 2 trial of trifluridine/tipiracil plus nivolumab in patients with heavily pretreated microsatellite‐stable metastatic colorectal cancer
Manish R. Patel; Gerald S. Falchook; K Hamada; Lukas Makris; Johanna C. Bendell · 2021 · Cancer Medicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Background Microsatellite‐stable (MSS) colorectal cancer (CRC) tends to be poorly immunogenic, with limited treatment options. In MSS CRC xenograft models, trifluridine/tipiracil (FTD/TPI) plus programed death 1 inhibitors resulted in synergistic antitumor activity and increased tumor immunogenicity. This phase 2 study evaluated FTD/TPI plus nivolumab in patients with MSS metastatic CRC. Methods This single‐arm, safety lead‐in study used a Simon's two‐stage design (enrolling 6 patients in the safety lead‐in, proceeding to stage 2 if ≥2 of the first 15 patients achieved a partial or co
Abstract by Manish R. Patel; Gerald S. Falchook; K Hamada; Lukas Makris; Johanna C. Bendell, Cancer Medicine (2021) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1002/cam4.3630