High-mobility group box 1 protein, histone H3 and histone H4 are not associated with peripheral hypoperfusion in sepsis: a retrospective cohort study
Bruna Cassia Dal Vesco; Ana Carolina de Miranda; Fernanda do Carmo De Stefani; Luis Gustavo Morello; Dalila Luciola Zanette; Luiz Eduardo Nunes Ferreira; Igor Alexandre Cortês de Menezes · 2026 · Einstein (São Paulo)
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
ABSTRACT Objective: The causal mechanisms of peripheral hypoperfusion in sepsis have not yet been fully elucidated. Therefore, this study aimed to investigate whether peripheral hypoperfusion in septic patients is associated with serum levels of damage-associated molecular patterns. Methods: A retrospective cohort study was conducted to compare serum levels of damage-associated molecular patterns - histone H3, histone H4, and high-mobility group box-1 protein (HMGB1) - with markers of tissue hypoperfusion - the peripheral perfusion index and the capillary refill time, using a single measuremen
Abstract by Bruna Cassia Dal Vesco; Ana Carolina de Miranda; Fernanda do Carmo De Stefani; Luis Gustavo Morello; Dalila Luciola Zanette; Luiz Eduardo Nunes Ferreira; Igor Alexandre Cortês de Menezes, Einstein (São Paulo) (2026) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.31744/einstein_journal/2026ao1615