Arc mediates intercellular tau transmission via extracellular vesicles
Mitali Tyagi; Eric de Hoog; Matthew Grega; Kaelan R. Sullivan; Alan Walker; Radhika Chadha; A. J. Northrop; Balázs Fábián · 2026 · Cell
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
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Abstract
Abstract Intracellular neurofibrillary tangles that consist of misfolded tau protein 1 cause neurodegeneration in Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Tau pathology spreads cell-to-cell 2 but the exact mechanisms of tau release and intercellular transmission remain poorly defined. Tau is released from neurons as free protein or in extracellular vesicles (EVs) 3–5 but the role of these different release mechanisms in intercellular tau transmission is unclear. Here, we show that the neuronal gene Arc is critical for packaging tau into EVs. Brain EVs purified from human tau
Abstract by Mitali Tyagi; Eric de Hoog; Matthew Grega; Kaelan R. Sullivan; Alan Walker; Radhika Chadha; A. J. Northrop; Balázs Fábián, Cell (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1016/j.cell.2026.06.008